TheGPManual

Mild-moderate pain, fever. First-line analgesic in most settings.

Mild-moderate pain, inflammation, fever, dysmenorrhoea

Musculoskeletal pain, osteoarthritis, acute gout, dysmenorrhoea, post-op pain

Mild-moderate pain (2nd line), antitussive, antidiarrhoeal

Moderate-severe pain when other analgesics insufficient

Severe pain, post-operative pain, cancer pain, dyspnoea in palliative care

Mild-moderate pain, fever, headache

URTI, community-acquired pneumonia, UTI, otitis media, H. pylori (combination)

Skin/soft tissue infections, dental infections, animal/human bites, complicated UTI, sinusitis

Atypical pneumonia, URTI, Chlamydia, typhoid, MDRSP (modified dosing)

Complicated UTI, typhoid, anthrax, GI infections, Gram-negative infections

Anaerobic infections, C. difficile (oral), BV, Trichomonas, H. pylori, dental infections, intra-abdominal infections

Chlamydia, atypical pneumonia, Lyme disease, malaria prophylaxis, acne, URTI

Uncomplicated lower UTI (females), prophylaxis of recurrent UTI, Pneumocystis jirovecii pneumonia (with sulfamethoxazole)

URTI, atypical pneumonia, H. pylori eradication (triple therapy), skin infections, MAC infection

Staphylococcal infections: cellulitis, impetigo, mastitis, wound infections, osteomyelitis

Hypertension, stable/vasospastic angina

Hypertension, heart failure, post-MI, diabetic nephropathy

Hypertension, stable angina, heart failure (with specialist initiation), AF rate control

Primary/secondary prevention of cardiovascular events, hyperlipidaemia

Oedema (cardiac, hepatic, renal), hypertension, acute pulmonary oedema

Heart failure (with EF ≤35%), primary hyperaldosteronism, resistant hypertension, cirrhotic ascites

ACS (with aspirin — DAPT), post-stent, stroke/TIA prevention, PAD

AF rate control (especially with heart failure), heart failure with reduced EF

AF thromboprophylaxis, VTE treatment/prevention, mechanical heart valves, antiphospholipid syndrome

VTE treatment/prevention, AF thromboprophylaxis, post-orthopaedic surgery prophylaxis

VTE treatment/prevention, AF thromboprophylaxis, post-orthopaedic surgery prophylaxis

DVT/PE treatment and prophylaxis, ACS (with PCI), pregnancy anticoagulation

Type 2 diabetes (first-line), PCOS (off-label)

Type 2 diabetes (2nd line or add-on)

Type 2 diabetes (add-on to metformin/sulphonylurea, or monotherapy if intolerant)

Type 2 diabetes (add-on; cardiovascular/renal benefit), heart failure with reduced/preserved EF

Type 1 and Type 2 diabetes (basal insulin component)

Acute bronchospasm in asthma/COPD, prevention of exercise-induced asthma

Persistent asthma (preventive), COPD (in combination)

COPD (maintenance bronchodilator), severe persistent asthma (add-on)

Asthma (preventive, esp. exercise-induced or allergic), allergic rhinitis

GERD, peptic ulcer disease, H. pylori eradication, NSAID-induced ulcer prophylaxis, Zollinger-Ellison syndrome

Chemotherapy/radiotherapy-induced nausea/vomiting, post-operative nausea/vomiting, hyperemesis gravidarum (off-label)

Nausea/vomiting, gastroparesis, gastro-oesophageal reflux (short-term)

Acute diarrhoea, chronic diarrhoea (in IBS, colostomy), traveller's diarrhoea

Depression, GAD, PTSD, OCD, panic disorder, PMDD, social anxiety disorder. Preferred SSRI in pregnancy.

Depression, OCD, bulimia nervosa, panic disorder

Depression (particularly with anxiety, insomnia, anorexia, weight loss)

Depression, GAD, social anxiety disorder, panic disorder

Depression, neuropathic pain (10–75 mg), migraine prophylaxis (10–75 mg), nocturnal enuresis (10–25 mg)

Schizophrenia, bipolar disorder (mania, depression, maintenance), augmentation in treatment-resistant depression

Short-term anxiety, alcohol withdrawal, acute seizures, muscle spasm, sedation

Epilepsy (generalised seizures, absence, myoclonic, focal), bipolar disorder, migraine prophylaxis

Focal and generalised epilepsy, Lennox-Gastaut, bipolar disorder

Focal epilepsy, juvenile myoclonic epilepsy, generalised tonic-clonic seizures (add-on)

Focal epilepsy, trigeminal neuralgia, bipolar disorder

Hypothyroidism (primary and secondary), TSH suppression (differentiated thyroid cancer)

Hyperthyroidism (Graves' disease, toxic nodule, toxic multinodular goitre)

Rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ectopic pregnancy

Rheumatoid arthritis, SLE, discoid lupus, malaria prophylaxis

Acute gout, gout prophylaxis, familial Mediterranean fever, pericarditis

Gout prophylaxis (urate-lowering therapy), uric acid/calcium oxalate renal stones

Vulvovaginal candidiasis, oropharyngeal/oesophageal candidiasis, invasive candidiasis, cryptococcal meningitis prophylaxis

HSV-1/2 (oral and genital herpes), VZV (chickenpox, shingles), HSV encephalitis, prevention in immunocompromised

Treatment and prevention of influenza A and B (start within 48h of symptoms)