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GP Clinical References & Evidence Base — NICE, WHO & International Guidelines

100+ evidence-based guidelines from NICE, WHO, ESC, ADA, BTS, KDIGO, RCOG and more — organised by GP specialty module

Comprehensive GP guideline reference

NICE, WHO, ESC & major sources across every specialty module

134 Guidelines & Sources 27 Specialty Modules Reviewed 2024–2026 Professional Use Only

40+

NICE Guidelines

12+

ESC / ACC / AHA

18+

WHO / Global

Medical Disclaimer: TheGPManual is a clinical reference tool for qualified healthcare professionals. Always verify critical decisions against the most recent guidelines, local protocols, and specialist consultation. The authors accept no liability for clinical decisions made solely on the basis of this reference.

Emergency Protocols

8 sources
1

AHA 2020 Guidelines for CPR & Emergency Cardiovascular Care

American Heart Association (AHA)2020Used in: Emergency Protocols
2

WAO Anaphylaxis Guidelines

World Allergy Organization2023Used in: Emergency Protocols
3

Surviving Sepsis Campaign: International Guidelines 2021

SCCM / ESICM2021Used in: Emergency Protocols
4

NICE CG134: Anaphylaxis — Assessment and Referral

NICE2020Used in: Emergency Protocols
5

NICE NG217: Status Epilepticus

NICE / Epilepsy Foundation2022Used in: Emergency, Neurology
6

JBDS DKA/HHS Management Guidelines

Joint British Diabetes Societies2023Used in: Emergency, Diabetes
7

ESH 2023 Hypertensive Emergency Guidelines

European Society of Hypertension2023Used in: Emergency, Hypertension
8

NICE NG185: Major Trauma

NICE2023Used in: Emergency Protocols

Cardiovascular

7 sources
1

ESC 2023 Guidelines: Acute Coronary Syndromes

European Society of Cardiology2023Used in: Cardiovascular — ACS
2

ESC 2020 Guidelines: Atrial Fibrillation

European Society of Cardiology2020Used in: Cardiovascular — AF
3

ESC 2021 Guidelines: Heart Failure

European Society of Cardiology2021Used in: Cardiovascular — Heart Failure
4

ESC/EAS 2019 Guidelines: Dyslipidaemia

ESC / European Atherosclerosis Society2019Used in: Cardiovascular — Lipid Management
5

QRISK3 — Cardiovascular Risk Calculator

QRISK / ClinRisk / BJGP 20172017Used in: Cardiovascular — Risk Assessment
6

NICE CG181: Cardiovascular Disease Risk Reduction

NICE2023Used in: Cardiovascular — Risk Assessment
7

NICE NG106: Chronic Heart Failure in Adults

NICE2023Used in: Cardiovascular — Heart Failure

Hypertension

5 sources
1

ESH 2023 Guidelines: Arterial Hypertension

European Society of Hypertension2023Used in: Hypertension — Classification, Drug Therapy
2

NICE NG136: Hypertension in Adults

NICE2023Used in: Hypertension — Drug Therapy, Special Populations
3

ACC/AHA 2017 High Blood Pressure Guidelines

American College of Cardiology / AHA2017Used in: Hypertension — Classification
4

NICE NG133: Hypertension in Pregnancy

NICE2023Used in: Hypertension — Special Populations, Gynaecology
5

JNC 8: Evidence-Based Guideline for Hypertension

James et al. JAMA 20142014Used in: Hypertension — Special Populations

Diabetes

6 sources
1

ADA Standards of Care in Diabetes 2024

American Diabetes Association2024Used in: Diabetes — All sections
2

ADA/EASD 2022 Consensus Report: Type 2 Diabetes

ADA / EASD2022Used in: Diabetes — Drug Therapy
3

NICE NG28: Type 2 Diabetes in Adults

NICE2022Used in: Diabetes — Drug Therapy, Special Populations
4

ISPAD Clinical Practice Guidelines 2022

International Society for Pediatric and Adolescent Diabetes2022Used in: Diabetes — Special Populations
5

JBDS DKA Guidelines (Adults)

Joint British Diabetes Societies2023Used in: Diabetes — DKA Protocol
6

NICE NG17: Type 1 Diabetes in Adults

NICE2022Used in: Diabetes — Insulin Initiation

Respiratory — Asthma & Paediatric

7 sources
1

NICE NG80: Asthma — Diagnosis, Monitoring & Management (Children)

NICE2023Used in: Respiratory — Paediatric Asthma
2

GINA 2024: Global Strategy for Asthma Management

Global Initiative for Asthma2024Used in: Respiratory — Asthma, Asthma-COPD
3

BTS/SIGN British Guideline on Asthma 2023

BTS / Scottish Intercollegiate Guidelines Network2023Used in: Respiratory — Paediatric Asthma, Asthma-COPD
4

Modified Asthma Predictive Index (mAPI) — Guilbert et al. NEJM 2006

New England Journal of Medicine2006Used in: Respiratory — Recurrent Wheeze
5

NICE NG78: Cystic Fibrosis Diagnosis and Management

NICE2017Used in: Respiratory — Cystic Fibrosis
6

ATS/ERS Standardisation of Spirometry 2022

American Thoracic Society / ERS2022Used in: Respiratory — Spirometry
7

NICE NG115: COPD — Spirometry and Diagnosis

NICE2019Used in: Respiratory — Spirometry, Asthma-COPD

Respiratory — Infections & Occupational

8 sources
1

NICE NG138: Community-Acquired Pneumonia

NICE2023Used in: Respiratory — Infections
2

CURB-65 Validation — Lim et al. Thorax 2003

British Thoracic Society2003Used in: Respiratory — Infections
3

UKHSA Pertussis (Whooping Cough) Guidelines

UK Health Security Agency2023Used in: Respiratory — Infections
4

NICE NG33: Tuberculosis Prevention, Diagnosis, Management

NICE2023Used in: Respiratory — Infections (TB)
5

NICE NG120: Antimicrobial Prescribing — Respiratory Tract Infections

NICE2023Used in: Respiratory — Infections
6

Murray et al. — Global AMR Burden 2019

The Lancet2022Used in: Respiratory — Infections
7

BOHRF: Occupational Asthma Guidelines

British Occupational Health Research Foundation2004Used in: Respiratory — Occupational Lung
8

HP Study Group Diagnostic Criteria 2020

AJRCCM2020Used in: Respiratory — Occupational Lung

Dermatology

4 sources
1

NICE NG190: Eczema — Atopic Dermatitis

NICE2023Used in: Dermatology — Treatment Ladder
2

NICE CG153: Psoriasis — Assessment and Management

NICE2022Used in: Dermatology — Treatment Ladder
3

BAD Guidelines: Acne Vulgaris 2020

British Association of Dermatologists2020Used in: Dermatology — Treatment Ladder
4

NICE NG12: Suspected Cancer — 2-Week Wait

NICE2023Used in: Dermatology — Photo Atlas, Referrals

ENT

6 sources
1

SIGN 117: Management of Sore Throat and Tonsillectomy

Scottish Intercollegiate Guidelines Network2010Used in: ENT — Sore Throat
2

NICE NG91: Acute Otitis Media in Children

NICE2018Used in: ENT — Otitis Media
3

NICE NG98: Otitis Media with Effusion

NICE2023Used in: ENT — Otitis Media
4

AAO-HNSF Clinical Practice Guidelines: Epistaxis 2020

American Academy of Otolaryngology2020Used in: ENT — Epistaxis
5

NICE NG234: Hearing Loss in Adults

NICE2023Used in: ENT — Hearing Loss
6

Bárány Society: Diagnostic Criteria for BPPV / Vestibular Disorders

Journal of Vestibular Research2022Used in: ENT — Vertigo

Gastroenterology

6 sources
1

Maastricht VI/Florence Consensus: H. pylori Management

Gut / EHSG2022Used in: Gastroenterology — Peptic Ulcer
2

NICE NG1: Gastro-Oesophageal Reflux Disease

NICE2023Used in: Gastroenterology — GERD
3

ACG Guidelines: Irritable Bowel Syndrome 2021

American College of Gastroenterology2021Used in: Gastroenterology — IBS Protocol
4

AASLD Guidelines: Hepatitis B Management 2023

American Association for Study of Liver Diseases2023Used in: Gastroenterology — Hepatitis
5

EASL Clinical Practice Guidelines: Hepatitis C 2020

European Association for Study of Liver2020Used in: Gastroenterology — Hepatitis
6

NICE NG129: IBD — Crohn's Disease and Ulcerative Colitis

NICE2023Used in: Gastroenterology — IBD

Mental Health

6 sources
1

NICE CG90: Depression — Recognition and Management

NICE2022Used in: Mental Health — Antidepressant Guide
2

NICE NG222: Depression in Adults (Updated)

NICE2022Used in: Mental Health — Antidepressant Guide
3

NICE CG185: Bipolar Disorder — Assessment and Management

NICE2023Used in: Mental Health — Scoring Tools
4

NICE NG87: ADHD Diagnosis and Management

NICE2019Used in: Mental Health
5

NICE CG178: Psychosis and Schizophrenia

NICE2023Used in: Mental Health
6

NICE NG189: Crisis Services — Mental Health

NICE2022Used in: Mental Health — Crisis Pathways

MSK & Rheumatology

5 sources
1

NICE NG59: Low Back Pain and Sciatica

NICE2023Used in: MSK — Back Pain
2

EULAR 2016 Recommendations: Gout Management

European League Against Rheumatism2016Used in: MSK — Gout
3

OARSI Guidelines: Knee and Hip Osteoarthritis 2019

Osteoarthritis Research Society International2019Used in: MSK — Osteoarthritis
4

NICE NG38: Fractures — Diagnosis and Management

NICE2023Used in: MSK — Fracture Recognition
5

NICE CG176: Shoulder Pain — Management

NICE2022Used in: MSK — Shoulder Disorders

Nephrology

5 sources
1

KDIGO 2012: Clinical Practice Guideline for AKI

Kidney Disease: Improving Global Outcomes2012Used in: Nephrology — AKI
2

KDIGO 2022: Clinical Practice Guideline for CKD

Kidney Disease: Improving Global Outcomes2022Used in: Nephrology — CKD
3

NICE NG203: CKD in Adults

NICE2023Used in: Nephrology — CKD
4

NICE NG148: AKI — Prevention, Detection, Management

NICE2019Used in: Nephrology — AKI
5

Renal Drug Handbook 5th Edition

Oxford University Press2023Used in: Nephrology — Renal Drug Dosing, Drug Database

Neurology

5 sources
1

NICE NG128: Stroke and TIA — Management

NICE2023Used in: Neurology — Stroke/TIA
2

ILAE 2017: Classification of Epilepsies

International League Against Epilepsy2017Used in: Neurology — Epilepsy
3

NICE CG150: Headache — Diagnosis and Management

NICE2023Used in: Neurology — Headache
4

NICE NG71: Parkinson's Disease

NICE2023Used in: Neurology — Movement Disorders
5

ESO Guidelines: Acute Ischaemic Stroke Treatment 2021

European Stroke Organisation2021Used in: Neurology — Stroke/TIA, Emergency

Ophthalmology

5 sources
1

NICE NG81: Glaucoma — Diagnosis and Management

NICE2022Used in: Ophthalmology — Glaucoma & AMD
2

RCOphth Guidelines: Age-Related Macular Degeneration

Royal College of Ophthalmologists2023Used in: Ophthalmology — Glaucoma & AMD
3

AAO Preferred Practice Pattern: Diabetic Retinopathy 2022

American Academy of Ophthalmology2022Used in: Ophthalmology — Diabetic Retinopathy
4

RCOphth: Red Eye — Primary Care Referral Guidelines

Royal College of Ophthalmologists2022Used in: Ophthalmology — Red Eye, Referral Urgency
5

NICE NG51: Visual Impairment — Assessment & Referral

NICE2022Used in: Ophthalmology — Referral Urgency, Eye Emergencies

Infectious Diseases

6 sources
1

NICE NG51: Sepsis — Recognition, Diagnosis and Early Management

NICE2023Used in: Infectious Diseases — Fever Workup
2

WHO AWaRe Classification: Antibiotic Stewardship 2023

World Health Organization2023Used in: Infectious Diseases — Stewardship, Respiratory
3

NICE NG111: Lower Urinary Tract Infections

NICE2023Used in: Infectious Diseases — UTI
4

NICE NG19: Travel Health — Malaria and Vaccinations

NICE / Fit for Travel NHS2023Used in: Infectious Diseases — Travel Medicine
5

BHIVA Guidelines: HIV Testing and Diagnosis 2023

British HIV Association2023Used in: Infectious Diseases — Fever Workup
6

NICE NG141: Skin and Soft Tissue Infections

NICE2019Used in: Infectious Diseases — Skin & Soft Tissue

Gynaecology & Obstetrics

4 sources
1

NICE NG201: Antenatal Care

NICE2023Used in: Gynaecology — Antenatal Care
2

FSRH UK-MEC: Contraception Eligibility 2023

Faculty of Sexual and Reproductive Healthcare2023Used in: Gynaecology — Contraception
3

NICE NG23: Menopause — Diagnosis and Management

NICE / British Menopause Society2023Used in: Gynaecology — Menopause & HRT
4

RCOG Green-top Guideline: Postpartum Haemorrhage

Royal College of Obstetricians and Gynaecologists2023Used in: Gynaecology — Obstetric Emergencies

General Surgery

5 sources
1

NICE NG12: Colorectal Cancer Recognition and Referral

NICE2023Used in: General Surgery — Colorectal
2

NICE CG188: Gallstone Disease — Initial Management

NICE2022Used in: General Surgery — Hepatobiliary
3

British Hernia Society Guidelines 2021

British Hernia Society2021Used in: General Surgery — Hernias
4

NCEPOD: Perioperative Care 2022

National Confidential Enquiry into Patient Outcome and Death2022Used in: General Surgery — Perioperative Care
5

Alvarado Score: Appendicitis Diagnosis (Ann Emerg Med 1986)

Alvarado. Ann Emerg Med1986Used in: General Surgery — Acute Abdomen

Paediatrics

6 sources
1

BNF for Children (BNFc) 2023/24

NICE / RCPCH / NPPG2024Used in: Paediatrics — Dose Calculator
2

UK WHO Growth Charts — RCPCH

Royal College of Paediatrics and Child Health2023Used in: Paediatrics — Development Milestones
3

NICE NG143: Fever in under-5s

NICE2019Used in: Paediatrics — Fever & Sepsis
4

UK Childhood Immunisation Schedule 2023

NHS / UK Health Security Agency2023Used in: Paediatrics — Vaccination Schedule
5

NICE CG89: Child Maltreatment — Recognition and Response

NICE2017Used in: Paediatrics — Safeguarding
6

NICE CG102: Meningitis and Meningococcal Septicaemia

NICE2023Used in: Paediatrics — Common Infections, Fever & Sepsis

Wound Management

4 sources
1

NICE CG179: Pressure Ulcers — Prevention and Management

NICE2022Used in: Wound Management — Pressure Ulcer
2

IWGDF Guidelines: Diabetic Foot 2023

International Working Group on the Diabetic Foot2023Used in: Wound Management — Diabetic Foot
3

SIGN 26: Chronic Leg Ulcer Management

Scottish Intercollegiate Guidelines Network2010Used in: Wound Management — Venous & Arterial
4

Wounds International: TIMERS Wound Bed Preparation 2022

Wounds International2022Used in: Wound Management — Wound Assessment

ECG Interpretation

4 sources
1

AHA/ACC/HRS 2017: ECG Standardization and Interpretation

American Heart Association / ACC / HRS2017Used in: ECG — Basics, Rhythms
2

ESC 2022 Guidelines: Ventricular Arrhythmias and SCD Prevention

European Society of Cardiology2022Used in: ECG — Rhythms, Conduction & Morphology
3

ESC 2017 Guidelines: STEMI Management

European Society of Cardiology2017Used in: ECG — ST Changes
4

Wellens' Sign — de Zwaan et al. Am Heart J 1982

American Heart Journal1982Used in: ECG — ST Changes, Quick Diagnosis

Asthma & COPD (Adult)

3 sources
1

GOLD 2024: Global Strategy for COPD

Global Initiative for COPD2024Used in: Asthma & COPD — Classification, Stepwise Therapy
2

NICE NG115: COPD in Adults

NICE2019Used in: Asthma & COPD — Classification
3

BTS/SIGN Asthma Guideline 2023

British Thoracic Society / SIGN2023Used in: Asthma & COPD — Exacerbation Protocol

Drug Database

3 sources
1

British National Formulary (BNF) 2024

NICE / BMJ Group2024Used in: Drug Database — All sections
2

Stockley's Drug Interactions 13th Edition

Pharmaceutical Press2022Used in: Drug Database — Interaction Checker
3

MHRA Yellow Card — Pharmacovigilance

Medicines and Healthcare products Regulatory Agency2024Used in: Drug Database

Lab Reference

4 sources
1

Harrison's Principles of Internal Medicine — Lab Values

McGraw-Hill Medical2022Used in: Lab Reference — All sections
2

ADA HbA1c Diagnostic Thresholds 2024

American Diabetes Association2024Used in: Lab Reference, Diabetes
3

ATA Guidelines: Thyroid Function Tests 2023

American Thyroid Association2023Used in: Lab Reference
4

WHO Reference Ranges for Blood Counts

World Health Organization2022Used in: Lab Reference

Calculators & Clinical Scores

4 sources
1

Wells Score for DVT — Wells et al. Lancet 1997

The Lancet1997Used in: Calculators — Clinical Scores
2

CHA₂DS₂-VASc Score — Lip et al. Chest 2010

Chest2010Used in: Calculators, Cardiovascular — AF
3

FRAX Tool — WHO Fracture Risk Assessment

WHO / University of Sheffield2023Used in: Calculators, MSK
4

Paediatric Glasgow Coma Scale — Teasdale & Jennett 1974

The Lancet / APLS1974Used in: Calculators — Paediatric Calculators

Pregnancy Drug Safety

3 sources
1

Briggs: Drugs in Pregnancy and Lactation 12th Ed

Briggs, Freeman & Towers — Wolters Kluwer2021Used in: Pregnancy Safety
2

FDA Pregnancy and Lactation Labeling Rule (PLLR)

U.S. Food & Drug Administration2015Used in: Pregnancy Safety
3

MHRA: Medicines in Pregnancy Safety Updates 2024

MHRA2024Used in: Pregnancy Safety

TB Guidelines

2 sources
1

WHO: Treatment of Drug-Susceptible TB 2022

World Health Organization2022Used in: TB & NTP
2

NICE NG33: Tuberculosis Prevention, Diagnosis, Management

NICE2023Used in: TB & NTP, Respiratory — Infections

CME & GP Examinations

3 sources
1

MRCGP Curriculum 2022

Royal College of General Practitioners2022Used in: CME — Examinations
2

MRCGP International (South Asia) Curriculum

RCGP International2024Used in: CME — Examinations
3

WONCA: Global Standard for Family Medicine Education

World Organization of Family Doctors2023Used in: CME

How TheGPManual Uses These References

Annual Review

Content is reviewed annually and updated when NICE, WHO, ESC, GINA, KDIGO and other bodies publish major guideline changes.

Clinical Adaptation

International guidelines are contextualised for primary care — practical thresholds, GP-relevant management steps, and referral criteria.

GP Validation

All protocols are reviewed by practising General Practitioners before publication to ensure accuracy and practical applicability.

Key Guideline Organisations

NICEWHOESCAHA/ACCBTS/SIGNGINAGOLDKDIGORCOGFSRHBADBHIVAILAEADA/EASDJBDSAASLDEASLAAORCOphthBNF/BNFcMHRAOARSIEULARIWGDFUKHSABOHRF

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Always verify critical decisions with current guidelines and specialist consultation.