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Clinical Practice Articles

NICE, WHO, AHA, ESC & Beyond — navigating guideline divergence with clinical precision

NICE vs AHA Hypertension ThresholdsQRISK3 vs PCE vs SCORE2 Risk CalculatorsSGLT2i vs GLP-1 Agonist: NICE vs ADALDL-C Targets: NICE vs ESCAntibiotic Prescribing: NICE vs IDSAScreening Guidelines: NHS vs USPSTFFramework for Guideline Navigation

About Clinical Practice Articles

Clinical practice articles for GPs — covering guideline navigation, evidence-based medicine, NICE vs international guideline comparisons, and the practical frameworks GPs need to make defensible clinical decisions when the evidence is uncertain or guidelines conflict.

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NICE vs WHO vs AHA: When the Guidelines Disagree — A GP's Field Guide
Clinical Practice16 min read14 April 2026

NICE vs WHO vs AHA: When the Guidelines Disagree — A GP's Field Guide

NICE says treat at 140/90 mmHg. AHA says 130/80 mmHg. WHO says 140/90 mmHg but with different drug choices. Your patient is sitting in front of you with a BP of 135/85 mmHg. Who do you follow? This guide cuts through the noise — comparing NICE, WHO, AHA, ESC, and other major bodies on the clinical questions that matter most in primary care, explaining why they diverge, and giving you a framework for making defensible, patient-centred decisions when the guidelines don't agree.

Dr. Sarah Mitchell
Dr. Sarah Mitchell· GP & Clinical Lead, Cardiovascular Medicine
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